S. Tanaka et al., STRAIN DIFFERENCE OF THE ADRENAL-CORTEX BETWEEN A J AND SM/J MICE, PROGENITORS OF SMXA RECOMBINANT INBRED GROUP/, Jikken Dobutsu, 44(2), 1995, pp. 127-130
The recombinant inbred (RI) mouse group is useful for genetic analysis
of a phenotype which is regulated by multiple loci. The female adrena
l cortex was compared histologically to detect the strain differences
between A/J and SM/J for the purpose of genetic analysis of adrenocort
ical morphogenesis using the SMXA RI group constructed between A/J and
SM/J. Clear morphological differences were found in the zona reticula
ris and X zone in addition to the significantly small body and adrenal
weights in SM/J. The z. reticularis was markedly thicker in SM/J than
in A/J and the X zone was constituted of vacuolated cells in A/J and
non-vacuolated cells in SM/J. The genetic control of these morphologic
al traits was analyzed using SMXA RI strains. The results suggest that
the thickness of the z. reticularis may be controlled by single locus
and that vacuolation of the X zone by 3 different loci between A/J an
d SM/J.