THE ENDOCRINE AND METABOLIC RESPONSE TO SURGICAL STRESS IN THE NEONATE

This study was conducted to investigate the newborn's response to surg ical trauma, Ten newborns and 10 infants as a control group undergoing similar surgical procedures were studied, All patients had moderate s urgical stress, and there was no difference between the groups regardi ng the degree of surgical trauma, Alterations in the serum cortisol an d growth hormone levels were investigated as parameters of the endocri ne response to surgical stress. The endocrine response, which was mani fested by elevations of both serum cortisol and growth hormone levels immediately postsurgery, disappeared within 48 hours after surgery. No difference in the endocrine response between these two groups was fou nd, The metabolic response to surgery was studied by measuring the ser um zinc, copper and magnesium levels and by determining the 24 hours' urine concentrations of these elements before and after surgery. The p lasma values of these elements decreased immediately after surgery and continued to decline significantly 24 hours after surgery. The 24 hou rs' urine concentrations of these elements increased significantly in the postoperative period, The changes observed after Surgery in newbor ns were more evident than those in infants. Copyright (C) 1995 by W.B. Saunders Company