EFFECT OF HUMIDITY-DEPENDENT CHANGES IN CRYSTAL-STRUCTURE ON THE SOLID-STATE FLUORESCENCE PROPERTIES OF A NEW HMG-COA REDUCTASE INHIBITOR

It has been shown previously that the disodium salt of a new HMG-CoA r eductase inhibitor (SQ-33600) is capable of existing as a number of hy drate species [1]. Three crystalline solid hydrates and one liquid cry stalline phase have been identified, each having a definite stability over a defined range of humidity. These forms have been found to exhib it varying fluorescence properties in their respective solid states, w ith differences in bandshapes and intensities being noted for each. Th ese spectral variations have been correlated with the known pseudopoly morphism of the compound.