Hg. Brittain et al., EFFECT OF HUMIDITY-DEPENDENT CHANGES IN CRYSTAL-STRUCTURE ON THE SOLID-STATE FLUORESCENCE PROPERTIES OF A NEW HMG-COA REDUCTASE INHIBITOR, Pharmaceutical research, 12(4), 1995, pp. 556-559
It has been shown previously that the disodium salt of a new HMG-CoA r
eductase inhibitor (SQ-33600) is capable of existing as a number of hy
drate species [1]. Three crystalline solid hydrates and one liquid cry
stalline phase have been identified, each having a definite stability
over a defined range of humidity. These forms have been found to exhib
it varying fluorescence properties in their respective solid states, w
ith differences in bandshapes and intensities being noted for each. Th
ese spectral variations have been correlated with the known pseudopoly
morphism of the compound.