6-IMINO-1,3-OXAZINES - A NEW CLASS OF HEPATOPROTECTANTS

Authors
RAMS VJ NATH M PATNAIK GK
Citation
Vj. Rams et al., 6-IMINO-1,3-OXAZINES - A NEW CLASS OF HEPATOPROTECTANTS, Bioorganic & medicinal chemistry letters, 5(7), 1995, pp. 695-698
Citations number
19
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
7
Year of publication
1995
Pages
695 - 698
Database
ISI
SICI code
0960-894X(1995)5:7<695:6-ANCO>2.0.ZU;2-C
Abstract
A convenient synthesis of polysubstituted 6-imino-1,3-oxazines (3,5,9) from corresponding ketene dithioacetals has been described and their conversion to pyrimidin-6-one (6) and pyrazolo[3,4-d]pyrimidine (8) st udied. The oxazines synthesized, have shown a significant hepatoprotec tive activity.