THE ENANTIOMER OF STRYCHNINE IS A WEAK ANTAGONIST OF THE INHIBITORY GLYCINE RECEPTOR

Authors
KNIGHT SD MILEDI R NGUYEN QT OVERMAN LE PAIRAUDEAU G
Citation
Sd. Knight et al., THE ENANTIOMER OF STRYCHNINE IS A WEAK ANTAGONIST OF THE INHIBITORY GLYCINE RECEPTOR, Bioorganic & medicinal chemistry letters, 5(7), 1995, pp. 749-752
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
7
Year of publication
1995
Pages
749 - 752
Database
ISI
SICI code
0960-894X(1995)5:7<749:TEOSIA>2.0.ZU;2-Z
Abstract
ent-Strychnine (2) was synthesized for the first time from (1R,4S)-(+) -4-hydroxy-2-cyclopentenyl acetate (3) by a slight modification of the sequence recently employed to prepare natural (-)-strychnine. ent-Str ychnine is about a 1000 fold weaker antagonist of the inhibitory glyci ne receptor expressed in oocytes than natural (-)-strychnine.