DUAL METALLOPROTEASE INHIBITORS .5. UTILIZATION OF BICYCLIC AZEPINONETHIAZOLIDINES AND AZEPINONETETRAHYDROTHIAZINES IN CONSTRAINED PEPTIDOMIMETICS OF MERCAPTOACYL DIPEPTIDES

Authors
SLUSARCHYK WA ROBL JA TAUNK PC ASAAD MM BIRD JE DIMARCO J PAN Y
Citation
Wa. Slusarchyk et al., DUAL METALLOPROTEASE INHIBITORS .5. UTILIZATION OF BICYCLIC AZEPINONETHIAZOLIDINES AND AZEPINONETETRAHYDROTHIAZINES IN CONSTRAINED PEPTIDOMIMETICS OF MERCAPTOACYL DIPEPTIDES, Bioorganic & medicinal chemistry letters, 5(7), 1995, pp. 753-758
Citations number
29
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
7
Year of publication
1995
Pages
753 - 758
Database
ISI
SICI code
0960-894X(1995)5:7<753:DMI.UO>2.0.ZU;2-W
Abstract
Incorporation of mercaptoacetyl or mercaptopropanoyl groups into azepi nonethiazolidine and azepinonetetrahydrothiazine carboxylic acids prov ided conformationally restricted peptidomimetics of Ala-Pro exhibiting potent dual activity in vitro versus ACE and NEP.