COMPARATIVE CONFORMATIONAL-ANALYSIS BETWEEN AN UNDECAMER OF DNA AND ITS APURINIC HOMOLOG

Authors
FOUILLOUX L BERTHET N COULOMBEAU C COULOMBEAU C DHEUANDRIES ML GARCIA J LHOMME J VATTON P
Citation
L. Fouilloux et al., COMPARATIVE CONFORMATIONAL-ANALYSIS BETWEEN AN UNDECAMER OF DNA AND ITS APURINIC HOMOLOG, Journal of molecular structure. Theochem, 330, 1995, pp. 417-422
Citations number
18
Categorie Soggetti
Chemistry Physical
Journal title
Journal of molecular structure. Theochem → ACNP
ISSN journal
01661280
Volume
330
Year of publication
1995
Pages
417 - 422
Database
ISI
SICI code
0166-1280(1995)330:<417:CCBAUO>2.0.ZU;2-Y
Abstract
Molecular modeling of a DNA undecamer and a corresponding DNA apurinic undecamer (d(CGCACXCACGC) d(GCGTGTGTGCG), X = A or apurinic site) has been performed using the JUMNA program. Among the possible structures , several are slightly distorted and correctly fit the experimental da ta obtained from NMR measurements. In these structures, the thymine ba se that faces the apurinic site lies inside the double helix.