SYNTHESIS AND IN-VIVO DISPOSITION STUDIES OF F-18 LABELED HFA-134A

Authors
FINCH JR BANKS WR HWANG DR SATTER MR EZZIDENE B MANTIL JC DIGENIS GA
Citation
Jr. Finch et al., SYNTHESIS AND IN-VIVO DISPOSITION STUDIES OF F-18 LABELED HFA-134A, Applied radiation and isotopes, 46(4), 1995, pp. 241-248
Citations number
13
Categorie Soggetti
Nuclear Sciences & Tecnology","Radiology,Nuclear Medicine & Medical Imaging
Journal title
Applied radiation and isotopes
ISSN journal
09698043 → ACNP
Volume
46
Issue
4
Year of publication
1995
Pages
241 - 248
Database
ISI
SICI code
0969-8043(1995)46:4<241:SAIDSO>2.0.ZU;2-W
Abstract
A rapid synthesis of the chlorofluorocarbon replacement compound 1,1,1 ,2-tetrafluoroethane (HFA-134a) was identified and utilized to prepare 99 + % radiochemically pure [F-18]HFA-134a in 20-35% radiochemical yi eld. Four rats were then exposed to no-carrier-added (NCA) [F-18]HFA-1 34a and monitored via coincidence detection. Following withdrawal of t he test atmosphere of [F-18]HFA-134a, the mean half-life of [F-18]HFA- 134a in four rats was determined to be 7.8 +/- 1.5 min following a 10 s exposure and 8.1 +/- 1.7 minutes following a 10 min exposure.