EFFECTS OF POLYETHYLENE-GLYCOL AS ADDITIVE IN MICROPELLET FORMULATIONS OF PENTAZOCINE HYDROCHLORIDE

Authors
MANDAL M MANDAL SC GUPTA BK
Citation
M. Mandal et al., EFFECTS OF POLYETHYLENE-GLYCOL AS ADDITIVE IN MICROPELLET FORMULATIONS OF PENTAZOCINE HYDROCHLORIDE, STP pharma sciences, 5(2), 1995, pp. 122-127
Citations number
11
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
STP pharma sciences → ACNP
ISSN journal
11571489
Volume
5
Issue
2
Year of publication
1995
Pages
122 - 127
Database
ISI
SICI code
1157-1489(1995)5:2<122:EOPAAI>2.0.ZU;2-T
Abstract
Micropellets of pentazocine hydrochloride, an opioid analgesic, were p repared using Eudragit RS100 and ethylcellulose, and the effects of in corporating polyethylene glycol 4000 in the micropellet matrices were studied. Polyethylene glycol 4000 was found to exert profound effects on drug release from the micropellets, and also influenced release kin etics. The mechanisms of drug release and kinetics are discussed in th e present work. Ethylcellulose/polyethylene glycol 4000 formulations s howed good potential for further work.