Background and Objective: The treatment of epidermal nevi is difficult
and often unsatisfactory. Many therapeutic approaches have been tried
, of which the surgical methods including lasers aim to avoid recurren
ces and hypertrophic scarring. Here we report the case of a widespread
, life-impairing epidermal nevus, summarize the available treatment mo
dalities, and discuss CO2 laser therapy with respect to the clinically
soft variants of these developmental defects. Study Design/Patients a
nd Methods: A patient with a widespread, recurrent, biopsy-proven epid
ermal nevus was treated with a 10,600-nm CO2 laser. After test treatme
nts in local anaesthesia, four sessions were performed under general a
naesthesia each with a follow-up time of 4 years to date. Results: CO2
laser vaporization resulted in complete removal of the treated nevus
without any obvious scarring. The patient is free of recurrence 4 year
s postoperatively. Conclusion. CO2 laser treatment of epidermal nevi i
s a useful modality in selected variants. (C) 1995 Wiley-Liss, Inc.