INFLUENCE OF NEUROLOGIC MANIFESTATIONS OF PRIMARY HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION ON DISEASE PROGRESSION

To determine the influence of neurologic manifestations of primary hum an immunodeficiency virus (HIV) infection on disease progression, 277 nonhemophiliac adults enrolled <1 year after HIV infection were studie d, Patients with neurologic manifestations during symptomatic primary HIV infection (PSI) (group N+; n = 23), with nonneurologic manifestati ons (group N-; n = 112) during PSI, and without any clinical manifesta tion during primary infection (group NPI; n = 142) were compared for d isease progression, Age at infection, sex, mode of infection and CD4() cell count at first visit did not differ between groups, In a Cox mo del, the relative risk (RR) of developing AIDS was 6.11 (95% confidenc e interval [CI], 1.94-19.28) in group Nf and 2.32 (95% CI, 0.93-5.83) in group N- compared with group NPI, The RR of AIDS onset after adjust ment for treatment and age at infection was, respectively, 4.65 (95% C I, 1.43-15.03) and 2.03 (95% CI, 0.80-5.19) in groups N+ and N-, Neuro logic manifestations of primary HIV infection are associated with an a ccelerated progression of disease.