Sa. Hienz et al., DEVELOPMENT AND CHARACTERIZATION OF A NEW MODEL OF HEMATOGENOUS OSTEOMYELITIS IN THE RAT, The Journal of infectious diseases, 171(5), 1995, pp. 1230-1236
Hematogenous osteomyelitis was produced in the tibia or the mandible o
f rats by drilling a hole into the bone, injecting sodium morrhuate, a
nd inoculating Staphylococcus aureus Phillips into the femoral vein, A
nimals were sacrificed after 2 weeks and examined, The infection was c
haracterized grossly and radiographically by bone deformation, histopa
thologically by a characteristic suppurative reaction, and microbiolog
ically by the recovery of S. aureus Phillips from the infected tissue,
These findings indicate that the model mimics human osteomyelitis wit
h respect to its inflammatory bone changes, In contrast to earlier rat
models in which bacteria were injected directly into the bone, this n
ew experimental model allows study of the initiating events of osteomy
elitis such as bacterial attachment and might assist as a model for bo
th prophylactic and therapeutic trials.