OXIDATIVE BEHAVIOR OF AMINOHALOGENBENZOPHENONES - INDIRECT DETERMINATION OF BENZODIAZEPINOOXAZOLES

An electroanalytical study of three aminohalogenbenzophenones: 2-amino -5-chlorobenzophenone (MCB), 2-amino-2',5-dichlorobenzophenone (DCB), and 2-amino-5-bromo-2'-fluorobenzophenone (BrFB); metabolites of the p sychotropic drugs benzodiazepinooxazoles and benzodiazepines, has been carried out at a glassy carbon electrode using different voltammetric techniques. The compounds studied are electrooxidizable in a hydroalc oholic medium (MeOH:H2O, 10:90), 0.5 M KCl, and a pH range of 1-13. Th e oxidation processes are irreversible and predominantly diffusion con trolled. On the basis of the oxidation process, voltammetric methods h ave been developed that allow the determination of aminohalogenbenzoph enones from 0.2 to 15 ppm for MCB and BrFB, and 0.2 to 14 ppm for DCB; with a reproducibility in terms of relative standard deviation (RSD) lower than 5.2% for 10 determinations of 10 ppm solutions of MCB, DCB, and BrFB. Detection limits of 200 ppb (mu g/L) for MCB and DCB, and 1 00 ppb for BrFB were obtained. The voltammetric method developed for D CB has been applied to the indirect determination of Cloxazolam in tab lets.