Md. Lagios, HETEROGENEITY OF DUCT CARCINOMA IN-SITU (DCIS) - RELATIONSHIP OF GRADE AND SUBTYPE ANALYSIS TO LOCAL RECURRENCE AND RISK OF INVASIVE TRANSFORMATION, Cancer letters, 90(1), 1995, pp. 97-102
Morphologic analysis of nuclear grade and extent of necrosis can provi
de reproducible classification of subclinical duct carcinoma in situ (
DCIS) which strongly separates DCIS into three risk groups. For subcli
nical lesions of small size, risk is largely limited to local recurren
ces only, half of which, however, are invasive events. Local recurrenc
es are seen much more frequently with high grade DCIS. Most local recu
rrences following breast conservation therapy represent residual disea
se in the immediate vicinity of the biopsy site. Stromal and cellular
host reactions may provide additional prognostic information.