Past epidemiological and clinical research has identified depression a
s the most common psychiatric disorder associated with headache. The p
resent study carried out in a neurology headache clinic showed that th
e major associations were with current anxiety disorders, especially p
anic and related conditions. These findings were particularly true of
the subgroup of migraine with aura; in the relatively few patients wit
h mood disorders, depression was nearly always comorbid with panic or
other anxiety disorders. Past history of depression was mainly a chara
cteristic of the tension headache group. These data are compatible wit
h the hypothesis that migraine, especially that with aura, panic disor
der and some forms of depressive illness are part of the same spectrum
.