OVARIAN-CANCER - COMPARISON OF FINDINGS WITH PERFLUOROCARBON-ENHANCEDMR-IMAGING, IN-111-CYT-103 IMMUNOSCINTIGRAPHY, AND CT

PURPOSE: To determine the accuracy of breath-hold gadolinium- and perf lubron-enhanced magnetic resonance (MR) imaging, immunoscintigraphy wi th indium-111-CYT-103 (planar and single photon emission computed tomo graphy [CT]), and contrast malerial-enhanced CT for the detection of o varian cancer prior to laparotomy. MATERIALS AND METHODS: Sixteen pati ents with primary (n = 3) or treated (n = 13) ovarian cancer underwent imaging of the abdomen and pelvis with each modality. All images were reviewed prospectively for tumor location, and results were compared with findings at surgery. RESULTS: With CT or MR imaging, tumor was de tected in 11 of 13 (85%) patients compared with 11 of 12 patients (92% ) with immunoscintigraphy. Per patient accuracy for CT was 81% compare d with 75% for MR imaging and 86% for immunoscintigraphy. For detectio n of individual sites of tumor, the sensitivity of MR imaging was high est (81%) compared with CT (51%, P <.001) and immunoscintigraphy (50%, P <.01). The combination of MR imaging and immunoscintigraphy depicte d 89% of sites of tumor involvement confirmed at laparotomy. CONCLUSIO N: MR imaging and immunoscintigraphy show promise for the evaluation o f patients with ovarian cancer.