REMARKABLY SELECTIVE METALLIZED-CARBON AMPEROMETRIC BIOSENSORS

The use of metallized carbon transducers results in remarkably selecti ve amperometric biosensors. Such focus on the transducer eliminates ma jor electroactive interferences in the first place, and hence circumve nts the need for anti-interference layers. The remarkable selectivity of metal-dispersed carbons is attributed to their strong, preferential , electrocatalytic action towards the detection of the enzymatically-l iberated hydrogen peroxide and reduced nicotinamide cofactor (NADH). S uch activity allows tuning of the operating potential to the region (0.1 to -0.2 V) where unwanted reactions do not occur. This article rev iews the development of metallized-carbon biosensors, with particular emphasis on metallized carbon-paste enzyme electrodes, miniaturized de vices based on electrochemical deposition of the metal/enzyme layer an d metal-dispersed sensor strips.