RADIATION-THERAPY AND BROMODEOXYURIDINE CHEMOTHERAPY FOLLOWED BY PROCARBAZINE, LOMUSTINE, AND VINCRISTINE FOR THE TREATMENT OF ANAPLASTIC GLIOMAS

Purpose: To conduct a Phase II study to evaluate the long-term efficac y and safety of radiotherapy combined with intravenous bromodeoxyuridi ne for patients with anaplastic glioma tumors. Methods and Materials: Between 1983 and 1987, study patients received 1.7-1.8 Gy radiation on ce a day, Monday through Friday, to a total dose of 60 Gy. On the Thur sday prior to beginning radiotherapy and for the next 5 weeks (6 weeks total), patients received a continuous 96 h intravenous infusion of b romodeoxyuridine at 0.8 g/m(2)/24 h; following radiotherapy, patients received procarbazine, lomustine (CCNU), and vincristine (PCV) for 1 y ear or until tumor progressed. Results: One-hundred thirty eight patie nts (median age, 43 years) were evaluable for analysis. Estimated 4-ye ar survival for the anaplastic astrocytoma (AA) stratum (n = 116) is 4 6%. For the astrocytoma (ASTRO) stratum (n = 22), the 6-year survival is estimated at 79%. Estimated 4-year progression-free survival for AA s is 42%, and for ASTROs, 68%. Whole brain irradiation was used in 23% and limited-field irradiation in 77%; patients receiving limited-fiel d irradiation had a better survival rate (p = 0.07). Total tumor resec tion was performed in 15%, partial resection in 53%, and biopsy only i n 32%. For the 81 patients with tumor recurrence, 34 (42%) are known t o have received additional treatment(s). For AA, fits of the Cox propo rtional hazards regression model showed that covariates individually p redictive of survival were younger age (p < 0.001), Karnofsky performa nce score (p = 0.04), and extent of surgery (p = 0.04); limited-field irradiation was not significant (p = 0.10). Major toxicities were rash during Weeks 1 through 6 requiring dose modification in 14%, Grade gr eater than or equal to III leukopenia in 18%, and Grade greater than o r equal to III thrombocytopeni in 9%. Conclusion: The study suggests t hat the bromadeoxyuridine-radiotherapy-PCV, compared with other publis hed therapies, can improve progression-free survival, and aggressive t reatment of ASTRO patients can lead to substantial increases in surviv al compared to published survival data.