THE NUMBER OF LUTEINIZING-HORMONE-RELEASING HORMONE IMMUNOREACTIVE NEURONS IS SIGNIFICANTLY DECREASED IN THE FOREBRAIN OF OLD-AGED FEMALE RATS

Authors
FUNABASHI T KIMURA F
Citation
T. Funabashi et F. Kimura, THE NUMBER OF LUTEINIZING-HORMONE-RELEASING HORMONE IMMUNOREACTIVE NEURONS IS SIGNIFICANTLY DECREASED IN THE FOREBRAIN OF OLD-AGED FEMALE RATS, Neuroscience letters, 189(2), 1995, pp. 85-88
Citations number
23
Categorie Soggetti
Neurosciences
Journal title
Neuroscience letters → ACNP
ISSN journal
03043940
Volume
189
Issue
2
Year of publication
1995
Pages
85 - 88
Database
ISI
SICI code
0304-3940(1995)189:2<85:TNOLHI>2.0.ZU;2-#
Abstract
To see changes in the number of luteinizing hormone-releasing hormone (LHRH) neurons during aging, young (3 months old)- and old (26 months old)-aged female rats, four of each, were used 4 weeks after ovariecto my for immunocytochemistry. The estimated total number (mean +/- SEM) of LHRH immunoreactive (ir) neurons in the forebrain of old-aged rats (353 +/- 34) was significantly smaller than that in young-aged rats (6 72 +/- 51). In the forebrain, the decrease in the number of LHRH-ir ne urons with age in rostral parts was greater than that in caudal parts, suggesting heterogeneous impairment of LHRH neurons in the rat forebr ain during aging.