Sh. Yoshida et al., PHYLOGENY OF LYMPHOCYTE HETEROGENEITY - CYTOTOXIC ACTIVITY OF CHANNELCATFISH PERIPHERAL-BLOOD LEUKOCYTES DIRECTED AGAINST ALLOGENEIC TARGETS, Developmental and comparative immunology, 19(1), 1995, pp. 71-77
Channel catfish peripheral blood contains leukocytes that function as
cytotoxic effecters directed against a variety of long-term cultured a
llogeneic, but not xenogeneic, targets. These effector cells are proba
bly distinct from macrophages, B cells, and nonspecific cytotoxic cell
s. The cytotoxic activity of these effector cells was inhibited with m
onoclonal antibody 1H5. Although this reagent appears to react with a
catfish cell surface molecule akin to the integrin LFA-1 present on th
e surface of nearly all leukocytes, it does not clarify the question a
s to whether or not these effecters are related to T cells.