IDENTIFICATION AND CHROMOSOMAL MAPPING OF A 3RD MOUSE RUNT-LIKE LOCUS

The Drosophila runt gene, which controls early events in embryogenesis , has been shown to have homologues in human and mouse. The human gene on 21q22 is involved in the t(8;21) associated with acute myeloid leu kemia. Two mouse runt-like loci encoding DNA-binding proteins have bee n identified. We report here the isolation and partial sequence of a m olecular clone of a third mouse runt-like locus. By using a panel of s omatic cell hybrids and interspecific backcross mice, we map the novel locus to the telomeric region Of mouse chromosome 4. (C) 1995 Academi c Press, Inc.