STRUCTURE-ACTIVITY-RELATIONSHIPS OF PHENYLPYRROLES AND BENZOYLPYRROLES

Antitumor, antimicrobial, and phytotoxic activities of the marine anti biotic pentabromopseudilin (1a) and related phenyl-, benzyl- and benzo yl pyrroles were compared. All activities depended strongly on the sub stituent pattern, with the natural compound la being the most active o ne, As judged from model reactions, a covalent bond of nucleophiles to the pyrrole system may be involved in the inhibition of macromolecula r syntheses.