SYNTHESIS OF SULFATED CEREBROSIDE ANALOGS HAVING MIMICS OF CERAMIDE AND THEIR ANTI-HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 ACTIVITIES

Authors
YOSHIDA H IKEDA K ACHIWA K HOSHINO H
Citation
H. Yoshida et al., SYNTHESIS OF SULFATED CEREBROSIDE ANALOGS HAVING MIMICS OF CERAMIDE AND THEIR ANTI-HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 ACTIVITIES, Chemical and Pharmaceutical Bulletin, 43(4), 1995, pp. 594-602
Citations number
16
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
43
Issue
4
Year of publication
1995
Pages
594 - 602
Database
ISI
SICI code
0009-2363(1995)43:4<594:SOSCAH>2.0.ZU;2-9
Abstract
Various sulfated cerebroside analogs, which are mimicks of cerebroside , have been prepared from per-O-acetylated D-glucose, per-O-acetylated D-galactose, and per-O-acetylated D-lactose with ethyleneglycol dodec yl ether, 3-docosyloxy-1-propanol, 2-hydroxymethyl-1,3-O-dimyristyl-1, 3-propanediol, and L-serine diamide derivatives as ceramide moieties. The synthesized sulfated glycolipids showed anti-HIV-1 activities.