AN ALKALINE KIT FORMULATION TO OBTAIN [TC-99M]MAG(3) IN HIGH RADIOCHEMICAL YIELDS

Authors
REYESHERRERA L FERROFLORES G LEZAMACARRASCO J GONZALEZZAVALA MA URENANUNEZ F AVILARAMIREZ E
Citation
L. Reyesherrera et al., AN ALKALINE KIT FORMULATION TO OBTAIN [TC-99M]MAG(3) IN HIGH RADIOCHEMICAL YIELDS, Journal of radioanalytical and nuclear chemistry, 199(6), 1995, pp. 507-516
Citations number
7
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Analytical","Nuclear Sciences & Tecnology
Journal title
Journal of radioanalytical and nuclear chemistry → ACNP
ISSN journal
02365731
Volume
199
Issue
6
Year of publication
1995
Pages
507 - 516
Database
ISI
SICI code
0236-5731(1995)199:6<507:AAKFTO>2.0.ZU;2-9
Abstract
An alkaline kit formulation (pH 9) to obtain [Tc-99m]MAG(3) with radio chemical purities over 98% has been developed, avoiding the addition o f filtered air to the vial, the use of large amounts of Tc-99m activit y (i.e., 3.7 GBq) or the reconstitution of large volumes. The use of t his radiopharmaceutical in mice showed a minimal accumulation in the h epatobiliary system (0.37 +/- 0.3 % I.D., 1 h postinjection) However, in rabbits we always obtained good image quality.