Adenosine monophosphate, inosine monophosphate, inosine, adenosine, gu
anosine, adenine, guanine, hypoxanthine, xanthine, uric acid, and pyri
midines bases were determined in cerebrospinal fluid (CSF) of 52 child
ren after simple febrile seizures and in a control group of 63 childre
n. There was no statistically significant difference between the two g
roups for any of these metabolites, suggesting that simple febrile sei
zures (SFS) neither significantly disturb the metabolism of nucleotide
s, nucleosides, or bases nor significantly deplete neuron adenosine AT
P levels. Therefore, they do not appear to constitute a threat of neur
onal damage.