ANTI-HIV AND ANTI-HCMV ACTIVITIES OF NEW AURINTRICARBOXYLIC ACID ANALOGS

A variety of aurintricarboxylic acid (ATA) polymer analogues were prep ared by substituting certain salicylic acid derivatives and carbonyl c ompounds for salicylic acid and formaldehyde in the ATA polymerization reaction. The new polymers were evaluated for prevention of the cytop athic effects of human immunodeficiency virus (HIV-1 and HIV-2) in MT- 4 cell culture, HIV-1 in CEM cell culture, and human cytomegalovirus ( HCMV) in HEL cell culture. The abilities of the analogues to inhibit s yncytium formation between HIV-1- or HIV-2-infected HUT-78 cells and u ninfected MOLT-4 cells were also evaluated. Several of the new analogu es were found to be equipotent with ATA and dextran sulfate against HI V-1, HIV-2 and HCMV. The anti-HIV potencies of the new substances para lleled their activities against HCMV. The antiviral activities of the new analogues probably result from inhibition of virion binding to the cell membrane.