AN EFFECT OF SOMATOSTATIN ON NEUROTENSIN SECRETION

A somatostatin analog (SMS201-995) was administered subcutaneously to six totally pancreatectomized (TP) patients at five dose levels from 0 mu g/kg (control) to 2.5 mu g/kg before ingestion of a liquid test me al, and plasma levels of neurotensin (NT) were measured. There were no significant differences in basal levels of NT between the doses of so matostatin. The NT levels were significantly elevated after ingestion of the test meal in the normal controls (n = 14). In the TP patients p ostprandial hypersecretion of NT was observed. The hypersecretion of N T in the patients was suppressed by SMS201-995 dose-dependently.