A CASE OF ACUTE MEGAKARYOBLASTIC LEUKEMIA WITH T(X-6)(P11.21-Q23) HAVING AN X-CHROMOSOME BREAKPOINT WITHIN A 450-KB REGION WHICH IS ALSO DISRUPTED IN 2 CLASSES OF SOLID TUMORS

Authors
REEVES BR KNIGHT JC RENWICK PJ JANI K KEMPSKI H
Citation
Br. Reeves et al., A CASE OF ACUTE MEGAKARYOBLASTIC LEUKEMIA WITH T(X-6)(P11.21-Q23) HAVING AN X-CHROMOSOME BREAKPOINT WITHIN A 450-KB REGION WHICH IS ALSO DISRUPTED IN 2 CLASSES OF SOLID TUMORS, Leukemia, 9(4), 1995, pp. 723-725
Citations number
13
Categorie Soggetti
Hematology,Oncology
Journal title
Leukemia → ACNP
ISSN journal
08876924
Volume
9
Issue
4
Year of publication
1995
Pages
723 - 725
Database
ISI
SICI code
0887-6924(1995)9:4<723:ACOAML>2.0.ZU;2-J
Abstract
Karyotype analysis of a case of acute megakaryoblastic leukaemia revea led an X;6 translocation as the sole abnormality. Using fluorescence i n situ hybridisation on leukaemic metaphases we demonstrated that the breakpoint on the X-chromosome occurred at p11.21, within a region spa nned by a YAC probe which has also been found to be disrupted in synov ial sarcomas and some papillary renal cell carcinomas.