PRIMARY CUTANEOUS CD30(KI-1)-POSITIVE LYMPHOMA OF NON-T, NON-B ORIGIN

A 71-year-old Japanese woman had two dome-shaped tumors on her right b uttock with several surrounding papules. Histological examination reve aled that large anaplastic cells and atypical lymphoid cells densely i nfiltrated the entire dermis. On immunohistochemical examination, Ki-1 , HLA-DR, CD25 (IL-2 receptor alpha), CD122 (IL-2 receptor beta), CD4, CD11c and CD68 were all positive in the tumor cells, whereas CD1a, CD 3, CD5, CD8 and CD19 were negative, Neither rearrangement of the T-cel l receptor beta, T-cell receptor gamma nor the immunoglobulin heavy-ch ain was seen. Ultrastructurally, most of the tumor cells contained thi ck bundles of intermediate filaments in the perinuclear cytoplasm, Thu s, this patient was diagnosed as having Ki-1-positive lymphoma of non- T, non-B origin. No recurrence or metastasis of the tumor has been obs erved in the last 2 years, although surgical resection was required 3 times before control was achieved.