THE ANTITUMOR EFFECT OF HYPERTHERMIA COMBINED WITH FLUOROURACIL AND ITS ANALOGS

The effectiveness of 5-fluorouracil (S-FU), FT-207 and FT-207 + uracil in combination with two repetitions of 43 degrees C hyperthermia in t he treatment of the Meth-A-Fibrosarcoma and Sarcoma-180 was examined i n vivo in BALB/c mice, The antitumor effect was evaluated in terms of inhibition of tumor growth by measuring the tumor for 7 days, The 5-FU concentration in each tumor was also monitored, Hyperthermia combined with FT-207 or FT-207 + uracil showed a synergistic effect for the in hibition of growth of both tumors which was not observed with 5-FU, Th ere were no significant differences in the intratumoral concentration of 5-FU in unheated or heated Sarcoma-180 for any drug treatment after the first hyperthermia treatment, except for significant decreases in the group given 5-FU with the first hyperthermia treatment, After the second hyperthermia treatment, significant decreases in the concentra tion of 5-FU and FT-207 + uracil were observed, In the Meth-A-Fibrosar coma, the intratumoral concentration of 5-FU decreased significantly i n the group given 5-FU and increased significantly in the group given FT-207 + uracil after the first hyperthermia treatment, while there we re significant decreases in 5-FU, FT-207 and FT-207 + uracil administe red with the second hyperthermia treatment, Hyperthermia combined with FT-207 or FT-207 + uracil is considered to be effective. (C) 1995 by Radiation Research Society