UPTAKE AND DISTRIBUTION OF SODIUM SELENITE IN RAT-BRAIN TUMOR

Eighteen weanling male Wistar rats with brain gliomas were divided int o three groups, which received 0., 2.0, 5.0 ppm selenium (Se) in their drinking water. The accumulation and retention of selenium in the bra in bearing tumor was investigated. Significantly higher concentrations of Se were observed in tumor tissue than normal brain tissue after ex posure to sodium selenite. Tumors were observed in the 2.0 mu g/g sele nium group. The difference in selenium concentration between the tumor tissue and contralateral normal brain tissue was not influenced by th e weight of brain or body, and water consumption. We observed that sel enium accumulated in tumor tissue more than in normal brain tissue.