CENTROSOME BEHAVIOR AND ORIENTATION OF CENTRIOLES UNDER THE ACTION OFENERGY-TRANSFER INHIBITORS

2,4-dinitrophenol, dinitrophenol together with deoxyglucose, sodium az ide and ouabain didn't alter cytoplasmic microtubule (MT) network of c ultured PK (pig kidney embryo) cells, meanwhile they induced an increa se in the average number of pericentriolar satellites and percentage o f centrioles with the primary cilium in these cells. Also all drugs st udied increase number of MTs attached to and oriented towards the cent rosome. Under the action of ouabain the total number of MTs around the centrosome doubled, meanwhile the number of long MTs emanating from t he centrosome increased more than 15 times. Under the action of all dr ugs studied, except sodium azide, the number of maternal centrioles or iented perpendicularly to the substrate surface increased significantl y from that in control cells.