EFFECTS OF IFENPRODIL ON STIMULATORY, DISCRIMINATIVE STIMULUS, AND CONVULSANT EFFECTS OF COCAINE

Ifenprodil, like cocaine, binds to the dopamine transporter and blocks uptake of dopamine. In this study, the ability of ifenprodil to mimic , enhance or block behavioral and toxic effects of cocaine was evaluat ed. Fixed-interval responding maintained by food presentation In rats was increased by cocaine but decreased by ifenprodil. Low rates of res ponding during timeout periods were also increased by cocaine but not ifenprodil. Ifenprodil neither increased locomotor activity nor augmen ted the stimulatory effect of cocaine; however, ifenprodil attenuated the stimulant effects of cocaine at doses 0.5 log unit lower than thos e required to reduce spontaneous activity when given alone. Ifenprodil neither substituted for nor augmented the discriminative stimulus eff ects of cocaine in rats discriminating 10 mg/kg cocaine from saline. I n contrast to cocaine, ifenprodil did not produce convulsions or signs of proconvulsant activity, and ifenprodil reduced the percentage of m ice convulsing in the presence of cocaine. These results suggest that pharmacological actions in addition to blockade of dopamine uptake or novel interactions with the dopamine transporter may contribute to the non-stimulant behavioral profile and cocaine-blocking actions of ifen prodil.