TUMORIGENESIS AND METASTASIS OF NEOPLASTIC KAPOSIS-SARCOMA CELL-LINE IN IMMUNODEFICIENT MICE BLOCKED BY A HUMAN-PREGNANCY HORMONE

Citation
Y. Lunardiiskandar et al., TUMORIGENESIS AND METASTASIS OF NEOPLASTIC KAPOSIS-SARCOMA CELL-LINE IN IMMUNODEFICIENT MICE BLOCKED BY A HUMAN-PREGNANCY HORMONE, Nature, 375(6526), 1995, pp. 64-68
Citations number
26
Categorie Soggetti
Multidisciplinary Sciences
Journal title
NatureACNP
ISSN journal
00280836
Volume
375
Issue
6526
Year of publication
1995
Pages
64 - 68
Database
ISI
SICI code
0028-0836(1995)375:6526<64:TAMONK>2.0.ZU;2-4
Abstract
KAPOSI's sarcoma (KS) occurs more often in men than in women and HIV-1 -associated KS has a high occurrence in homosexual men (over 30%). Mos t cultures of KS tumours yield cells with properties of hyperplastic ( not malignant) endothelial cells under the control of several cytokine s(1-7). The role of HIV-1 may be in promoting high levels of some cyto kines and providing stimulation to angiogenesis by the HIV-1 Tat prote in(8), which synergizes with basic fibroblast growth factor in promoti ng these effects(9), Here,ve describe an immortalized AIDS-KS cell lin e (KS Y-1) and show that these cells produce malignant metastatic tumo urs in nude mice and are killed in vitro and in vivo (apparently by ap optosis) by a pregnancy hormone, the beta-chain of human chorionic gon adotropin. Similarly, chorionic gonadotropin kills KS SLK, cells from another neoplastic cell line (established from a non-HIV-associated KS )(10), as well as the hyperplastic KS cells from clinical specimens gr own in short-term culture, but does not kill normal endothelial cells, These results provide evidence that KS can evolve into a malignancy a nd have implications for the hormonal treatment of this tumour.