HEMOLYTIC-DISEASE OF THE NEWBORN DUE TO ANTI-M

A patient with haemolytic disease of the newborn (HDN) due to anti-hi which required exchange transfusion is described. Anti-hi antibodies a re usually assumed to be naturally occurring and to consist of immunog lobin M (IgM); many however have an immunoglobin G (IgG) component. In view of this and the described occurrence of HDN, recommendations are made regarding the management of a pregnancy in which anti-hi antibod ies are detected.