Da. Dmello et al., RELATIONSHIP BETWEEN CONCURRENT SUBSTANCE-ABUSE IN PSYCHIATRIC-PATIENTS AND NEUROLEPTIC DOSAGE, The American journal of drug and alcohol abuse, 21(2), 1995, pp. 257-265
The use of a structured diagnostic interview (The Schedule for Affecti
ve Disorders and Schizophrenia) with 58 consecutively admitted general
adult psychiatric patients revealed that 62.1% of them abused alcohol
and 58.6% had a substance use disorder. The drug abusers did not diff
er significantly from the nonabusers on mean psychoticism (Brief Psych
iatric Rating Scale) scores. However, they received higher doses of an
tipsychotic agents (mean daily dose 1022 mg CPZ EQ (SD = 614) vs 609 m
g CPZ EQ (SD = 481); z = 2.58, p < .01) to achieve stabilization. The
clinical implications of this finding are discussed.