ANALYSIS OF VACCINES PREPARED FROM ARMADILLO-DERIVED MYCOBACTERIUM-LEPRAE - RESULTS OF AN INTER-LABORATORY STUDY COORDINATED BY THE WORLD-HEALTH-ORGANIZATION

Authors
YOUNG S MCADAM K SMITH P FINE P REES RJW BANERJEE D MCDERMOTTLANCASTER D YOUNG D CONVIT J BRENNAN P SHINNICK T WALKER L VANLANDINGHAM R BLOOM B ANDERSEN A HASLOV K
Citation
S. Young et al., ANALYSIS OF VACCINES PREPARED FROM ARMADILLO-DERIVED MYCOBACTERIUM-LEPRAE - RESULTS OF AN INTER-LABORATORY STUDY COORDINATED BY THE WORLD-HEALTH-ORGANIZATION, International journal of leprosy and other mycobacterial diseases, 63(1), 1995, pp. 48-55
Citations number
1
Categorie Soggetti
Pathology,"Tropical Medicine
Journal title
International journal of leprosy and other mycobacterial diseases → ACNP
ISSN journal
0148916X
Volume
63
Issue
1
Year of publication
1995
Pages
48 - 55
Database
ISI
SICI code
0148-916X(1995)63:1<48:AOVPFA>2.0.ZU;2-H
Abstract
Preparations of armadillo-derived Mycobacterium leprae used in vaccine trials were analyzed using a combination of morphological, chemical a nd immunological criteria. When compared to more recent preparations, vaccine lots prepared in 1984 and 1985 were found to contain fewer int act bacilli and lower amounts of M. leprae antigens. These differences may be characteristic of the original preparations, or alternatively, may have arisen during prolonged storage. The early vaccine lots were those used in the recently published Venezuela trial.