C. Lienhardt et al., INTEROBSERVER VARIABILITY IN THE ASSESSMENT OF NERVE FUNCTION IN LEPROSY PATIENTS IN ETHIOPIA, International journal of leprosy and other mycobacterial diseases, 63(1), 1995, pp. 62-76
One of the major problems in leprosy is to detect any change in nerve
function early enough so as to increase the chances of recovery and pr
event disability. Several tests have been developed to assess nerve fu
nction and are used in leprosy control programs worldwide, but they ar
e frequently performed by different workers on different occasions and
under variable conditions. In this study we investigated the variabil
ity between different groups of observers in the assessment of nerve f
unction in leprosy patients in Ethiopia. Sensory function was assessed
by using a set of nylon monofilaments (NF) and a ball-point pen (BP),
and motor function was assessed by using voluntary motor testing (VMT
). We also studied the variability between observers in the assessment
of the clinical signs of neuritis. Duplicate measurements were perfor
med in random order on 50 leprosy patients by two physio-technicians a
nd on 50 other patients by two health assistants. The percent agreemen
t between observers was calculated for each single nerve, and weighted
kappa statistics were used to assess whether agreement was better tha
n expected due to chance alone. Systematic differences between observe
rs were evaluated using the Wilcoxon signed rank test. On sensory test
ing, interobserver variability was found to be related to the training
and experience of the observer, to the nerve tested, and to the neuro
logical status of the patient.When tests were performed by physiotechn
icians, we observed 32% to 58% agreement with the NF test and 71% to 8
4% agreement with the BP test, measured on different scales. After wei
ghting for the scale difference, the agreement seemed comparable with
these methods but the differences in measurements with the BP test wer
e found to be dependent upon the neurological status of the patient. T
he variability between observers differed according to the nerve teste
d, and there was some evidence of systematic differences between obser
vers with both methods. When performed by the health assistants, agree
ment was between 34% and 46% with the NF and between 66% and 82% with
the BP tests. After weighting for the scale difference, the agreement
seemed comparable but the BP was not liable to the systematic differen
ces seen in the NF results. These differences could be attributed to t
he differences in the experience of the workers with these tests. With
the VMT, small variability between observers was found for all nerves
tested, except the facial nerve, when performed by both the physio-te
chnicians and by the health assistants (72% to 98% agreement). Change
agreement, however, could not be excluded since the ratings were extre
mely homogenous. The assessment of neuritis signs was extremely variab
le between observers (14% to 41% agreement), with evidence of a system
atic difference between observers. Implications of these findings are
discussed with the view to improving comparability of the nerve functi
on tests under held conditions for early detection of nerve damage in
leprosy patients.