From 1980 to 1991, 56 cases of pyogenic liver abscess were treated at
the Cleveland Clinic. The most frequently used treatment was percutane
ous catheter drainage of the abscess under computed tomography (CT) gu
idance (39 patients), followed by CT-guided aspiration without cathete
r drainage (10 patients). Six patients were initially treated by open
operative drainage; another five were operated upon after CT guided dr
ainage had failed. One patient with advanced pancreatic cancer was tre
ated with antibiotics only. The overall mortality rate was 12.5% (7/56
). It is clear that the preferred method of treatment for pyogenic hep
atic abscess is now CT guided catheter drainage. Operative drainage is
reserved for patients who fail to respond to percutaneous drainage or
in whom surgery is indicated for other purposes. Aspiration without c
atheter drainage is a modality that needs further evaluation to define
its indications.