ARE TRANSPORTER ASSOCIATED WITH ANTIGEN-PROCESSING (TAP) AND TAPASIN CLASS-I MHC CHAPERONES

Authors
SOLHEIM JC CARRENO BM HANSEN TH
Citation
Jc. Solheim et al., ARE TRANSPORTER ASSOCIATED WITH ANTIGEN-PROCESSING (TAP) AND TAPASIN CLASS-I MHC CHAPERONES, The Journal of immunology, 158(2), 1997, pp. 541-543
Citations number
39
Categorie Soggetti
Immunology
Journal title
The Journal of immunology
ISSN journal
00221767 → ACNP
Volume
158
Issue
2
Year of publication
1997
Pages
541 - 543
Database
ISI
SICI code
0022-1767(1997)158:2<541:ATAWA(>2.0.ZU;2-6
Abstract
Class I MHC heavy chains associate with many proteins in the endoplasm ic reticulum, including TAP, calnexin, calreticulin, and the newly def ined tapasin molecule. Recent studies have begun to resolve the nature of how these proteins interact with class I as well as the functional significance of each of these interactions. We propose here that TAP and tapasin are leading candidates to be highly specific chaperones fo r the class I molecule.