COEXPRESSION OF TRK FAMILY MEMBERS AND LOW-AFFINITY NEUROTROPHIN RECEPTORS IN RAT DORSAL-ROOT GANGLION NEURONS

Authors
KASHIBA H NOGUCHI K UEDA Y SENBA E
Citation
H. Kashiba et al., COEXPRESSION OF TRK FAMILY MEMBERS AND LOW-AFFINITY NEUROTROPHIN RECEPTORS IN RAT DORSAL-ROOT GANGLION NEURONS, Molecular brain research, 30(1), 1995, pp. 158-164
Citations number
24
Categorie Soggetti
Neurosciences
Journal title
Molecular brain research → ACNP
ISSN journal
0169328X
Volume
30
Issue
1
Year of publication
1995
Pages
158 - 164
Database
ISI
SICI code
0169-328X(1995)30:1<158:COTFMA>2.0.ZU;2-Z
Abstract
We examined the colocalization of trk family and low-affinity neurotro phin receptor (LANR) mRNAs by means of in situ hybridization histochem istry in rat dorsal root ganglion (DRG) neurons. About 35-40%, 5%, and 15-20% of DRG neurons were positive for trkA, trkB, and trkC mRNAs, r espectively. Each member of the trk family was coexpressed with LANR. The trkB mRNA-expressing neurons essentially lacked trkA and trkC mRNA s, and most of trkA and trkC mRNAs-expressing neurons (85-90%) belonge d to different subpopulations, suggesting that they are involved in di fferent functions.