SENSOR METHODS FOR USE WITH MICRODIALYSIS AND ULTRAFILTRATION

The use of biosensors for metabolite and drug monitoring utilizing dif ferent micro dialysis sampling techniques is reviewed. After a brief i ntroduction in the methods of microdialysis and ultrafiltration, gener al parameters that characterize the response of micro sensor devices ( sensitivity range, sample requirements, response time) and the efficie ncy of micro sampling (charge and osmotic effects) are discussed. A va riety of practical examples of biosensors used in micro sampling techn iques are described. It is concluded that the intrinsic properties of biosensors are well suited for microdialysate monitoring, and that the progress in sensor technologies will open up the possibility of the u se of integrated biosensor/microdialysis probe systems.