Many important psoriasis therapies were discovered by chance observati
on of improvement. During the last decade, the significant ability of
cyclosporine to treat psoriasis focused research and subsequent develo
pment of therapeutic options on the immunologic arena. New therapies i
nvestigated before the cyclosporine revolution are reviewed and includ
e new developments in phototherapy, therapy oi psoriasis with drugs cu
rrently approved for other diseases, and new drugs developed specifica
lly for psoriasis. Cyclosporine and other immune therapies currently i
n development are discussed.