ADVANCES IN KAPOSIS-SARCOMA

Kaposi's sarcoma is a multifocal neoplasm that has recently yielded se veral clues to its etiology and pathogenesis. This tumor stems to occu r when a predisposed individual (genetically susceptible or immunologi cally deficient) comes in contact with an infectious or environmental agent. Recent studies have strongly supported the association of a new herpesvirus (human herpesvirus 8 or Kaposi's sarcoma herpesvirus) wit h this disease. Current approaches to therapy Include the use of chemo therapy, interferons, cytokines, antiangiogenesis, antivirals, and dif ferentiating agents.