PHARMACOLOGY OF CANNABINOID RECEPTORS

Two subtypes of cannabinoid receptors, CB1 and CB2, have been describe d to date, although future investigations may elucidate other receptor s. The actions of cannabimimetic agents via CB1 receptors in brain are mediated by G(I/O) to inhibit adenylate cyclase and Ca2+ channels. Li ttle is known about signal transduction mechanisms utilized by CB2 rec eptors. Three classes of agonist ligands regulate cannabinoid receptor s: cannabinoid, aminoalkylindole, and eicosanoid derivatives. Cannabin oid receptors produce analgesia and modify cognition, memory, locomoto r activity, and endocrine functions in mammals.