Primary prevention aims at reducing the incidence of a disorder. The f
irst step in primary prevention involves documenting the magnitude of
the problem and identifying risk factors. Consistent with primary prev
ention practices, we review the national and international epidemiolog
ical data on suicide mortality and then discuss the implications these
data hold for primary prevention. Our approach is novel because we sy
stematically examine the suicide epidemiology data by gender and cultu
re. Suicide mortality appears to be highest among individuals (e.g., y
oung adult married females in some Papua New Guinea regions; older adu
lt, isolated, White males in the United States) for whom such behavior
is culturally sanctioned. Thus, an important target for primary preve
ntion may be local cultures of gender and suicide.