ROLE OF ARRAY OF OXYGEN-ATOMS OF ARTEMISININ IN THE ANTIMALARIAL ACTIVITY .1. MOLECULAR MODELING STUDIES TO INVESTIGATE COMPOUNDS WITH ARTEMISININ-LIKE ARRAY OF OXYGEN-ATOMS

Authors
BHONSLE JB
Citation
Jb. Bhonsle, ROLE OF ARRAY OF OXYGEN-ATOMS OF ARTEMISININ IN THE ANTIMALARIAL ACTIVITY .1. MOLECULAR MODELING STUDIES TO INVESTIGATE COMPOUNDS WITH ARTEMISININ-LIKE ARRAY OF OXYGEN-ATOMS, Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry, 34(5), 1995, pp. 380-388
Citations number
37
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry → ACNP
ISSN journal
03764699
Volume
34
Issue
5
Year of publication
1995
Pages
380 - 388
Database
ISI
SICI code
0376-4699(1995)34:5<380:ROAOOO>2.0.ZU;2-A
Abstract
The energy-minimised conformers of compounds 15 to 40 have been built on the computer using QUANTA and CHARMm softwares and compared with ar temisinin (1) for similarities in the stereochemical disposition of ox ygen atoms. The distances between oxygen atoms in these compounds and in 1, and the closeness of the fit of each individual compound with 1 have been tabulated. Photographs of the raster displays of the compoun ds exhibiting best fit are presented.