GLYCOLAMIDE ESTERS OF 6-METHOXY-2-NAPHTHYLACETIC ACID AS POTENTIAL PRO-DRUGS - SYNTHETIC AND SPECTRAL STUDIES

Authors
WADHWA LK SHARMA PD
Citation
Lk. Wadhwa et Pd. Sharma, GLYCOLAMIDE ESTERS OF 6-METHOXY-2-NAPHTHYLACETIC ACID AS POTENTIAL PRO-DRUGS - SYNTHETIC AND SPECTRAL STUDIES, Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry, 34(5), 1995, pp. 408-415
Citations number
19
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry → ACNP
ISSN journal
03764699
Volume
34
Issue
5
Year of publication
1995
Pages
408 - 415
Database
ISI
SICI code
0376-4699(1995)34:5<408:GEO6AA>2.0.ZU;2-E
Abstract
6-Methoxy-2-naphthylacetic acid (6-MNA; 1), the active metabolite of n ewly developed NSAID nabumetone (2) has been modified using prodrug ap proach. A number of glycolamide ester prodrugs of 6-MNA have been synt hesized by masking the free carboxyl group of 6-MNA, mainly responsibl e for gastric damage, in order to obtain NSAIDs with improved therapeu tic index. The structures of these derivatives have been established o n the basis of elemental and spectral analyses.