QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP STUDY OF 8-STYRYLXANTHINES AS A2-SELECTIVE ADENOSINE ANTAGONISTS

Authors
OJHA TN TIWARI S SHARMA RC SINGH P
Citation
Tn. Ojha et al., QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP STUDY OF 8-STYRYLXANTHINES AS A2-SELECTIVE ADENOSINE ANTAGONISTS, Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry, 34(5), 1995, pp. 452-455
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry → ACNP
ISSN journal
03764699
Volume
34
Issue
5
Year of publication
1995
Pages
452 - 455
Database
ISI
SICI code
0376-4699(1995)34:5<452:QSRSO8>2.0.ZU;2-O
Abstract
Through quantitative structure-activity relationship (QSAR) analysis o f some 8-styrylxanthines as A2-selective adenosine antagonists, it is derived that for better potency ligands, electron withdrawing groups a t ortho- and para-positions while bulky groups at both the meta-positi ons of the phenyl ring in styryl substituent are advantageous.