P. Imming, SYNTHESIS OF THE FIRST PENICILLIN DERIVATIVES WITH MEDIUM-SIZED LACTAM RING AND OF RELATED THIAZOLIDINES, Archiv der pharmazie, 328(3), 1995, pp. 207-215
The novel concept of penicillin derivatives 4 with a medium-sized inst
ead of a beta-lactam ring is presented. Two synthetic paths were inven
ted, resulting in the evaluation of the synthetic potential in the suc
cinic, glutaric, and adipic acid series. A number of novel penicillin-
derived thiazolidines were prepared, notably the derivatives 16 and 22
with anellated 7- and 13-membered lactam ring.